People with cancer may experience serious chronic health and psychological sequelae including accelerated functional decline, fatigue, musculoskeletal symptoms, psychological distress, a higher risk of developing comorbid conditions and reduced quality of life. This presentation will summarise the evidence of the efficacy of exercise in counteracting the detrimental side effects of cancer and its treatment. The evidence emerging from epidemiological studies suggesting exercise confers benefit to cancer outcomes will be presented. Practical strategies to incorporate exercise into clinical practice will also be discussed.