Colorectal cancer causes more deaths in Australia than breast cancer or prostate cancer, despite the fact that the majority of these deaths could have been prevented by screening. There is a large spectrum of risk of colorectal cancer across the population with many people at a very low risk, but a substantial proportion at increased risk. If we knew how to estimate personal risk of colorectal cancer, we could provide more screening to those at high risk where it is needed most, and less to those at low risk. Many risk factors have been identified (for example being older, being overweight, eating high amounts of red meat and having a family history). A recently identified risk factor, is a relatively cheap DNA test on a saliva sample, that gives a personal score of colorectal cancer risk based on the individual’s genetic markers (called SNPs). This presentation demonstrates that this SNP-based risk can be used to identify people at higher and lower risks of colorectal cancer, and by combining it with family history, can be used to guide screening appropriate to personal level of risk.